Overview
| 别名 | Discoidin; CUB and LCCL domain-containing protein 2; CUB; LCCL and coagulation factor V/VIII-homology domains protein 1; Endothelial and smooth muscle cell-derived neuropilin-like protein |
| 基因名 | DCBLD2 |
| UniProt ID | Q96PD2 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6S7-F1-E5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 85 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | DCBLD2 is a transmembrane protein that is highly expressed in various cancers, including colorectal cancer and lung adenocarcinoma, where it promotes tumor occurrence, development, and metastasis. DCBLD2 overexpression is associated with poor prognosis and drug resistance in these cancers. Mechanistically, DCBLD2 induces epithelial-mesenchymal transition (EMT) and angiogenesis, leading to increased migration and metastasis. Additionally, ultra-rare damaging variants in DCBLD2 are likely risk factors contributing to the complex disease process of relapsing polychondritis, a rare autoimmune disease. A homozygous nonsense mutation in DCBLD2 has also been identified as a candidate cause of restrictive cardiomyopathy, developmental delay, and spasticity, potentially through dysregulation of calcium and reactive oxygen species homeostasis. |
检测原理