Overview
| 别名 | DnaJ homolog subfamily C member 7; Tetratricopeptide repeat protein 2; TPR repeat protein 2 |
| 基因名 | DNAJC7 |
| UniProt ID | Q99615 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 4O1-L3-K5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 56 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | DnaJ heat shock protein family (Hsp40) member C7 (DNAJC7) is a co-chaperone that regulates protein folding by interacting with HSP70 and HSP90 in an ATP-dependent manner. It features a conserved J-domain with an HPD motif that stimulates HSP70 ATPase activity and a TPR2B domain that binds client proteins, such as steroid receptors and tau monomers. DNAJC7 facilitates substrate recycling by enabling the retrograde transfer of clients from HSP90 back to HSP70. It plays a critical neuroprotective role by targeting inert tau monomers to prevent their aggregation and by mitigating the toxicity of FUS and TDP-43. Clinically, loss-of-function mutations in DNAJC7 are well-established genetic factors in amyotrophic lateral sclerosis (ALS). These mutations impair tau seeding suppression and aggregate clearance, linking the protein to the pathogenesis of ALS and other tauopathies. |
检测原理