Overview
| 别名 | Golgi reassembly-stacking protein 1; Golgi peripheral membrane protein p65; Golgi phosphoprotein 5; GOLPH5; Golgi reassembly-stacking protein of 65 kDa; GRASP65 |
| 基因名 | GRASP65 |
| UniProt ID | Q9BQQ3 |
| 反应种属 | Human |
| 应用 | WB,IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4T7-I9-T9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 46 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000; IHC-1:100-1:200; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Golgi reassembly-stacking protein 1 (GORASP1), also known as GRASP65, is a crucial peripheral membrane protein encoded by the GORASP1 gene in humans. It plays a significant role in maintaining the structure of the Golgi apparatus by facilitating the stacking of Golgi cisternae and linking them into larger ribbons through its interactions with other proteins, such as GM130 and p115. GORASP1 is essential for the proper functioning of the Golgi complex, particularly in protein sorting and modification processes. Additionally, it is implicated in apoptosis, as it serves as a substrate for caspase-3, leading to Golgi fragmentation during cell death. Dysregulation or mutations in GORASP1 have been associated with various diseases, including congenital disorders of glycosylation and immunodeficiencies. |
检测原理