Overview
| 别名 | Brother of CDO; Protein BOC |
| 基因名 | BOC |
| UniProt ID | Q9BWV1 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4Y7-N6-Q1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 121 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Brother of CDO (BOC) is a cell surface receptor encoded by the BOC gene, belonging to the immunoglobulin superfamily and characterized by multiple fibronectin type III repeats, which localize it to the plasma membrane and axonal growth cones. BOC forms complexes with its homolog CDON and participates in a positive feedback loop with myogenic transcription factors, notably MyoD, to promote myogenic differentiation; it also interacts with ABL and activates JNK, thereby supporting neuronal differentiation and neurite outgrowth. The protein’s expression is tightly regulated during development and is downregulated by oncogenic Ras, which blocks differentiation, but forced re-expression of BOC can restore differentiation programs in muscle and neuronal cells. Disease associations primarily involve its role in tumorigenesis, as altered BOC expression or function can disrupt normal differentiation pathways, contributing to the development and progression of cancers such as rhabdomyosarcoma and potentially other malignancies where cell adhesion and differentiation are dysregulated. |
检测原理