Overview
| 别名 | Protein amnionless [Cleaved into: Soluble protein amnionless] |
| 基因名 | AMN |
| UniProt ID | Q9BXJ7 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 4B4-F8-A8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 47 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000; IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Amnion associated transmembrane protein (AMN) is a type I transmembrane protein primarily found embedded in the outer membrane of kidney cells and cells lining the small intestine. It functions by binding to cubilin, anchoring it to the cell membrane, and is essential for vitamin B12 uptake from food. AMN helps transfer the cubilin-vitamin B12 complex into intestinal cells, from where the vitamin is released into the bloodstream. In the kidneys, AMN and cubilin participate in reabsorbing certain proteins that would otherwise be excreted in urine. Additionally, AMN is thought to modulate bone morphogenetic protein (BMP) receptor function. Mutations in the AMN gene can lead to hereditary megaloblastic anemia, a condition characterized by abnormally large red blood cells and neurological complications due to impaired vitamin B12 absorption, which affects DNA formation, protein production, cellular energy generation, and fat metabolism. |
检测原理