Overview
| 别名 | Caspase recruitment domain-containing protein 14; CARD-containing MAGUK protein 2; Carma 2 |
| 基因名 | CARD14 |
| UniProt ID | Q9BXL6 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 2Z2-F1-A3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 113 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Caspase recruitment domain family member 14 (CARD14) is a scaffold protein belonging to the membrane-associated guanylate kinase (MAGUK) family and the CARD-CC protein family, characterized by a caspase-associated recruitment domain (CARD) and a coiled-coil (CC) domain. CARD14 is primarily expressed in the skin, where it plays a crucial role in assembling multiprotein complexes at specialized plasma membrane regions and activating the NF-κB signaling pathway, which regulates genes involved in immune responses, inflammation, and cell survival. The protein interacts with BCL10 and MALT1 to form a CBM signalosome, facilitating NF-κB activation and modulating skin cell homeostasis, including the regulation of filaggrin (FLG) expression. Pathogenic mutations in CARD14 are associated with several skin disorders, most notably psoriasis and pityriasis rubra pilaris, as well as atopic eczema, due to dysregulated inflammatory signaling in the skin. |
检测原理