Overview
| 别名 | Membrane frizzled-related protein; Membrane-type frizzled-related protein |
| 基因名 | MFRP |
| UniProt ID | Q9BY79 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8U4-T8-H2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 62 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Membrane frizzled-related protein (MFRP) is a single-pass transmembrane protein predominantly expressed in the retinal pigment epithelium (RPE) of the vertebrate eye, where it plays a crucial role in eye development and retinal homeostasis. MFRP belongs to the frizzled-related protein family and is involved in the Wnt signaling pathway, mediating cell fate determination and maintaining the organization of the retinal lipidome, particularly by regulating the enrichment of docosahexaenoic acid (DHA) and very long-chain polyunsaturated fatty acids (VLC-PUFAs) essential for photoreceptor function. It interacts with other RPE-specific transmembrane proteins, such as adiponectin receptor 1 (ADIPOR1) and inward rectifier potassium channel 13 (KCNJ13), ensuring their correct localization within the apical membrane of RPE cells, which is vital for visual function. Mutations in MFRP disrupt these processes and are associated with ocular diseases including nanophthalmos, posterior microphthalmia, retinitis pigmentosa, foveoschisis, and optic disc drusen, often leading to retinal degeneration and vision loss. |
检测原理