Overview
| 别名 | CUGBP Elav-like family member 4; CELF-4; Bruno-like protein 4; CUG-BP- and ETR-3-like factor 4; RNA-binding protein BRUNOL-4 |
| 基因名 | CELF4 |
| UniProt ID | Q9BZC1 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2H9-V5-N9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 51 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:3000-1:4000; IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | CUGBP Elav-like family member 4 (CELF4) is a neuron-enriched, cytoplasmic RNA-binding protein that regulates the stability, localization, and translation of target mRNAs. It preferentially binds to U/GU-rich elements in the 3′UTRs of transcripts and also influences the alternative splicing of genes such as MAPT and TNNT2. CELF4 targets a significant portion of the excitatory neuron transcriptome, particularly mRNAs encoding synaptic and excitability-related proteins, thereby shaping synaptic transmission and plasticity. Functionally, it acts as a potent negative regulator of neuronal excitability and a translational repressor of synaptic development programs. Clinically, CELF4 dysfunction is implicated in epilepsy and neurodevelopmental disorders. Loss of CELF4 in models leads to a complex neurological phenotype characterized by epileptic seizures, hyperexcitability, and abnormal sensory processing, underscoring its critical role in maintaining neuronal homeostasis. |
检测原理