Overview
| 别名 | Regulator of nonsense transcripts 3B; Nonsense mRNA reducing factor 3B; Up-frameshift suppressor 3 homolog B; hUpf3B; Up-frameshift suppressor 3 homolog on chromosome X; hUpf3p-X |
| 基因名 | UPF3B |
| UniProt ID | Q9BZI7 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 2N6-A3-V2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 57 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | UPF3B regulator of nonsense mediated mRNA decay (UPF3B) is a key component of the mRNA surveillance machinery that identifies and degrades transcripts containing premature termination codons. It localizes to both the nucleus and cytoplasm, where it associates with the exon junction complex and interacts with UPF1 and UPF2 to couple translation termination with mRNA decay. UPF3B contains an RNA-recognition motif-like domain and a NOPS-L region that mediate high-affinity binding to RNA and the assembly of the NMD complex. Pathogenic variants in UPF3B are a known cause of X-linked intellectual disability, which may be accompanied by autism, epilepsy, and schizophrenia. These mutations often disrupt the interaction between UPF3B and UPF2, leading to impaired NMD efficiency and neurodevelopmental pathology. |
检测原理