Overview
| 别名 | E3 ubiquitin-protein ligase TRIM31; Tripartite motif-containing protein 31 |
| 基因名 | TRIM31 |
| UniProt ID | Q9BZY9 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 7P7-O2-O7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 48 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:10000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | E3 ubiquitin-protein ligase TRIM31 (TRIM31) is a member of the tripartite motif (TRIM) protein family, functions as an E3 ubiquitin ligase and plays a significant role in various cellular processes, including cell proliferation, inflammation, and tumorigenesis. Characterized by its RING finger, B-box, and coiled-coil domains, TRIM31 is involved in the ubiquitination of target proteins, regulating their stability and function. Notably, TRIM31 has been found to be upregulated in gastric adenocarcinoma, suggesting its potential as a biomarker for early-stage gastric cancer. Despite its overexpression in cancer tissues, TRIM31 can negatively regulate cell growth, indicating a complex role in tumor biology. Additionally, TRIM31 has been implicated in metabolic disorders, as it mitigates liver steatosis and insulin resistance by promoting the degradation of Rhbdf2, thereby improving insulin signaling and reducing inflammation. |
检测原理