Overview
| 别名 | Tripartite motif-containing protein 5; RING finger protein 88; RING-type E3 ubiquitin transferase TRIM5 |
| 基因名 | TRIM5 |
| UniProt ID | Q9C035 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3W4-P3-C1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 56 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | TRIM5 (Tripartite Motif Containing 5) is a crucial protein in the innate immune response, primarily known for its role in restricting retroviral infections, particularly HIV-1. It functions by recognizing and binding to the viral capsid, leading to the disassembly of the virus shortly after entry into the host cell. This antiviral activity is mediated through its RING domain, which also exhibits E3 ubiquitin ligase activity, influencing various signaling pathways involved in immune responses and inflammation. Moreover, polymorphisms in the TRIM5 gene have been associated with variations in HIV-1 infection outcomes, indicating its potential as a genetic factor influencing disease susceptibility. Beyond viral infections, TRIM5 has been implicated in autoimmune diseases such as systemic lupus erythematosus (SLE), where its expression correlates with disease severity, suggesting that it may also modulate immune responses in pathological contexts. |
检测原理