Overview
| 别名 | Nonsense-mediated mRNA decay factor SMG9 |
| 基因名 | SMG9 |
| UniProt ID | Q9H0W8 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 1B1-S5-T8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 57 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | SMG9 nonsense mediated mRNA decay factor (SMG9) is a cytoplasmic regulatory subunit of the SMG1–8–9 kinase complex, essential for the nonsense-mediated mRNA decay (NMD) surveillance pathway. It is recruited alongside SMG1 and SMG8 to stalled ribosomes, where it facilitates the efficient association of SMG1 with SMG8 and enables the SMG1-mediated phosphorylation of UPF1. This phosphorylation is a critical step that triggers NMD and the subsequent degradation of mRNAs containing premature termination codons. By controlling the stability of both aberrant and specific physiological transcripts, SMG9 plays a vital role in the development of the brain, heart, and eyes. Biallelic loss-of-function mutations in SMG9 are well-established causes of heart and brain malformation syndrome, a congenital disorder characterized by structural brain malformations, heart defects, and developmental delay. |
检测原理