Overview
| 别名 | Caspase recruitment domain-containing protein 9; hCARD9 |
| 基因名 | CARD9 |
| UniProt ID | Q9H257 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5I4-W3-J2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 62 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Caspase recruitment domain family member 9 (CARD9) is a critical adapter protein that mediates innate and adaptive immune responses, particularly against fungal pathogens. It features an N-terminal CARD domain for homophilic interactions with BCL10 and a C-terminal coiled-coil region for oligomerization. CARD9 functions as a scaffold within the CARD9-BCL10-MALT1 (CBM) complex, acting downstream of C-type lectin receptors like Dectin-1 to activate NF-κB and MAPK signaling pathways. This process triggers the production of pro-inflammatory cytokines such as TNFα and IL-6 via Syk and PKCδ. Clinically, biallelic loss-of-function mutations in CARD9 result in CARD9 deficiency, a rare autosomal recessive primary immunodeficiency. This condition is characterized by impaired Th17 immunity and extreme susceptibility to invasive fungal infections, including candidiasis and deep dermatophytosis, often presenting with central nervous system involvement. |
检测原理