Overview
| 别名 | Semaphorin-6C; Semaphorin-Y; Sema Y |
| 基因名 | SEMA6C |
| UniProt ID | Q9H3T2 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9U2-E6-W9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 99 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Semaphorin-6C (SEMA6C) is a member of the semaphorin family of proteins, which are primarily known for their roles in axon guidance and neuronal development. SEMA6C is a transmembrane protein that interacts with various receptors, including plexins, to mediate signaling pathways essential for cell communication and migration. Recent studies have highlighted its involvement in cancer biology, where SEMA6C expression is linked to tumor growth and progression. Specifically, silencing SEMA6C in cancer cells leads to growth arrest and increased levels of cell cycle inhibitors, indicating its role in promoting cell proliferation. Furthermore, SEMA6C has been implicated in the activation of signaling pathways involving FAK and YAP, which are critical for cellular survival under stress conditions. Dysregulation of SEMA6C may contribute to various diseases, including certain cancers and neurodevelopmental disorders. |
检测原理