Overview
| 别名 | TBC1 domain family member 17 |
| 基因名 | TBC1D17 |
| UniProt ID | Q9HA65 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 1Z9-A1-S6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 72 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | TBC1 domain family member 17 (TBC1D17), is a probable RAB GTPase-activating protein (GAP) that primarily inhibits RAB8A/B function, reducing Rab8 recruitment to tubules from the endocytic recycling compartment (ERC) and thereby suppressing Rab8-mediated endocytic trafficking, such as that of the transferrin receptor. Predicted to enable GTPase activator activity, it participates in retrograde transport from endosomes to Golgi, regulation of autophagy, and vesicle-mediated transport pathways, with localization in the cytosol; it spans 344 amino acids in humans and has paralogs like TBC1D15. Diseases linked to TBC1D17 include glaucoma, normal tension, and primary open angle glaucoma. |
检测原理