Overview
| 别名 | Regulator of nonsense transcripts 2; Up-frameshift suppressor 2 homolog; hUpf2 |
| 基因名 | UPF2 |
| UniProt ID | Q9HAU5 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 3P2-P8-S2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 147 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | UPF2 regulator of nonsense mediated mRNA decay (UPF2) is a key component of the nonsense-mediated mRNA decay (NMD) pathway, which serves as a quality control mechanism to eliminate mRNAs containing premature stop codons. UPF2 is part of a post-splicing multiprotein complex, interacting with UPF1 and UPF3 proteins, and plays a central role in the formation of the surveillance complex that recognizes and degrades faulty mRNAs. It acts as an adaptor between Stau1 and UPF1, stimulating UPF1's catalytic activity and facilitating mRNA nuclear export and surveillance. UPF2 is primarily located in the perinuclear region and is expressed in various tissues, including the brain, where it has been implicated in regulating synaptic spine density and neuronal plasticity. Alterations in UPF2 function can impact neural processes and behavior, suggesting a potential link to neurodevelopmental or neuropsychiatric conditions. |
检测原理