Overview
| 别名 | Claspin; hClaspin |
| 基因名 | CLSPN |
| UniProt ID | Q9HAW4 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 7B9-A1-M9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 151 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Claspin (CLSPN) is a crucial regulatory protein involved in the DNA damage response and replication checkpoint pathways. It functions as a mediator that transmits signals from the ataxia telangiectasia and Rad3-related (ATR) kinase to checkpoint kinase 1 (Chk1), facilitating the activation of the cellular response to replication stress. Claspin is essential for maintaining genomic stability by stabilizing stalled replication forks and ensuring proper DNA repair mechanisms. Dysregulation or mutations in CLSPN have been associated with various diseases, particularly cancer, where its altered expression can lead to increased sensitivity to genotoxic stress and contribute to tumorigenesis. Notably, Claspin has been shown to interact with BRCA1, further linking it to breast cancer susceptibility. |
检测原理