Overview
| 别名 | Cadherin-related family member 5; Mu-protocadherin; Mucin and cadherin-like protein; Mucin-like protocadherin; MLPCDH |
| 基因名 | CDHR5 |
| UniProt ID | Q9HBB8 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2B9-L3-D8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 88 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Cadherin-related family member 5 (CDHR5), also known as MLPCDH or MUCDHL, is a member of the cadherin superfamily and encodes a transmembrane protein with essential roles in cell adhesion and organ morphogenesis. It features four main functional domains: a cadherin domain, a mucin-like domain, a proline-rich region, and a PDZ binding motif. CDHR5 is predominantly expressed in epithelial cells of various organs, including the kidneys and lungs. Its expression has been linked to several cancers; notably, low levels of CDHR5 are associated with poor prognosis in renal cell carcinoma, colorectal cancer, and liver cancer. In pancreatic ductal adenocarcinoma (PDAC), increased CDHR5 expression correlates with tumor progression and metastasis. |
检测原理