Overview
| 别名 | Ferroportin; Ferroportin-1; Iron-regulated transporter 1; Solute carrier family 40 member 1 |
| 基因名 | SLC40A1 |
| UniProt ID | Q9NP59 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5E7-D4-B6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 62 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Solute carrier family 40 member 1 (SLC40A1), commonly known as ferroportin, is the only known mammalian exporter of inorganic iron. This multipass transmembrane protein is essential for maintaining systemic iron homeostasis by transporting ferrous iron (Fe2+) from the cytoplasm of duodenal enterocytes, macrophages, and hepatocytes into the circulatory system. Its activity is tightly regulated by the hormone hepcidin, which binds to ferroportin to induce its internalization and degradation, thereby limiting iron export. Clinically, mutations in SLC40A1 are the cause of hemochromatosis type 4, also known as ferroportin disease. This condition is characterized by iron accumulation within macrophages and hepatocytes, leading to hepatic iron overload, which differs from classical hemochromatosis by its distinct pattern of iron sequestration. |
检测原理