Overview
| 别名 | Podocin |
| 基因名 | NPHS2 |
| UniProt ID | Q9NP85 |
| 反应种属 | Human |
| 应用 | IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1G8-L1-L1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 42 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | NPHS2 stomatin family member, podocin (NPHS2), encoded by the NPHS2 gene, is a critical protein primarily located in the kidneys, specifically within podocytes that form the filtration barrier of the glomeruli. This integral membrane protein, composed of 383 amino acids, plays a vital role in maintaining glomerular permeability by acting as a linker between the plasma membrane and the cytoskeleton, facilitating proper assembly of the slit diaphragm—a structure essential for filtering blood while retaining proteins. Mutations in NPHS2 are predominantly associated with congenital nephrotic syndrome, a severe kidney disorder that manifests in infancy and can lead to end-stage renal disease by early childhood. Additionally, NPHS2 mutations can cause other forms of nephrotic syndrome that develop later in life, such as infantile nephrotic syndrome. |
检测原理