Overview
| 别名 | Endothelial cell-specific molecule 1; ESM-1 |
| 基因名 | ESM1 |
| UniProt ID | Q9NQ30 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 4E5-U6-Q1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 20 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Endothelial cell specific molecule 1 (ESM1), also known as endocan, is a secreted cysteine-rich proteoglycan primarily expressed in the vascular endothelium of the lungs and kidneys. It features an N-terminal cysteine-rich domain and a C-terminal dermatan sulfate chain that are essential for its biological activity. ESM1 plays a critical role in regulating angiogenesis and inflammation; it binds to fibronectin to enhance the bioavailability of VEGF-A and interacts with growth factors like HGF/SF and FGF-2. Additionally, ESM1 modulates leukocyte recruitment by inhibiting the interaction between LFA-1 and ICAM-1. Clinically, ESM1 is recognized as a biomarker for tumor aggressiveness and vascularization. Its overexpression is strongly correlated with poor prognosis, increased invasion, and drug resistance in various malignancies, including gastric cancer, clear cell renal cell carcinoma, and hepatoblastoma. |
检测原理