Overview
| 别名 | 1-phosphatidylinositol 4; 5-bisphosphate phosphodiesterase beta-1; PLC-154; Phosphoinositide phospholipase C-beta-1; Phospholipase C-I; PLC-I; Phospholipase C-beta-1; PLC-beta-1 |
| 基因名 | PLCB1 |
| UniProt ID | Q9NQ66 |
| 反应种属 | Human,Mouse |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2D4-J2-P9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 138 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | 1-Phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1) is an enzyme that catalyzes the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP2) into inositol 1,4,5-trisphosphate (IP3) and diacylglycerol (DAG), key secondary messengers in various signaling pathways. This enzyme plays a pivotal role in intracellular signal transduction, particularly in response to G-protein-coupled receptor activation, leading to increased intracellular calcium levels and subsequent cellular responses. Dysregulation of PLCB1 has been implicated in several diseases, particularly hepatocellular carcinoma (HCC), where its overexpression is associated with tumor progression and poor prognosis. Studies have shown that elevated PLCB1 expression correlates with advanced tumor stages and promotes cell proliferation while inhibiting apoptosis in HCC cells. Additionally, PLCB1 is involved in other conditions such as schizophrenia and myotonic dystrophy. |
检测原理