Overview
| 别名 | Protein diaphanous homolog 3; Diaphanous-related formin-3; DRF3; MDia2 |
| 基因名 | DIAPH3 |
| UniProt ID | Q9NSV4 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6O7-M2-B1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 136 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Diaphanous related formin 3 (DIAPH3) is a member of the formin homology protein family, primarily functioning as an actin nucleation and elongation factor essential for the assembly of F-actin structures such as actin cables and stress fibers. It plays a critical role in cellular processes including cytokinesis, cell shape changes, adhesion, and division by promoting actin polymerization in both the cytoplasm and nucleus, often in a Rho-dependent manner. DIAPH3 also interacts with microtubules to stabilize their structure and is involved in the regulation of selenoamino acid metabolism through interactions with ribosomal proteins, potentially influencing selenoprotein expression. Disease associations include its implication in auditory neuropathy, autosomal dominant 1 (AUNA1), and its overexpression has been linked to the progression of certain cancers, such as pancreatic cancer, by altering cytoskeletal dynamics and cellular metabolism. |
检测原理