Overview
| 别名 | TBC1 domain family member 13 |
| 基因名 | TBC1D13 |
| UniProt ID | Q9NVG8 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7R3-D7-H4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 46 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | TBC1 domain family member 13 (TBC1D13) is a cytosolic and membrane-associated GTPase-activating protein (GAP) involved in intracellular vesicle trafficking. Characterized by a conserved TBC (Tre-2/Bub2/Cdc16) domain, it functions as a specific regulator of the small GTPase RAB35. Through this interaction, TBC1D13 modulates Rab-dependent membrane dynamics, including the insulin-stimulated translocation of the glucose transporter GLUT4 to the plasma membrane in adipocytes, implicating it in systemic glucose homeostasis. While widely expressed and structurally defining a component of the transport machinery, TBC1D13 is not currently linked to specific monogenic disorders, though its function suggests relevance to metabolic regulation and cellular transport pathways. |
检测原理