Overview
| 别名 | Calmodulin-regulated spectrin-associated protein 3; Protein Nezha |
| 基因名 | CAMSAP3 |
| UniProt ID | Q9P1Y5 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2C2-Q5-Y6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 134 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Calmodulin regulated spectrin associated protein family member 3 (CAMSAP3) is a key microtubule-organizing protein that specifically binds to the minus-end of non-centrosomal microtubules, regulating their dynamics and organization within the cell. It enables both actin filament binding and microtubule minus-end binding activities, playing crucial roles in microtubule cytoskeleton organization, regulation of organelle positioning, and maintenance of cell-cell junctions such as the zonula adherens. CAMSAP3 is essential for the formation and polarity of basal bodies and the central pair of microtubules in motile cilia, influencing ciliary structure, synchronized beating, and overall function in multiciliated cells. Loss of CAMSAP3 disrupts these processes, leading to defects reminiscent of primary ciliary dyskinesia, including impaired mucociliary clearance, subfertility, and respiratory issues. Additionally, CAMSAP3 has been implicated in protecting lung carcinoma cells from epithelial-mesenchymal transition (EMT) by regulating microtubule dynamics and suppressing Akt activity. Diseases associated with CAMSAP3 mutations include autosomal dominant and recessive forms of deafness. |
检测原理