Overview
| 别名 | Death domain-associated protein 6; Daxx; hDaxx; ETS1-associated protein 1; EAP1; Fas death domain-associated protein |
| 基因名 | DAXX |
| UniProt ID | Q9UER7 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 3H3-R7-E1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 81 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Death domain associated protein (DAXX) is a multifunctional protein that serves as a specific histone H3.3 chaperone, playing a vital role in replication-independent chromatin assembly. In the nucleus, it partners with ATRX to deposit H3.3-H4 dimers at pericentric heterochromatin, telomeres, and PML nuclear bodies, thereby influencing gene expression and centromere regulation. DAXX also acts as a transcriptional repressor for factors such as p53 and ETS1. In the cytoplasm, it interacts with the Fas receptor to activate the JNK signaling pathway via ASK1, mediating apoptotic responses. Its activity is tightly regulated by post-translational modifications, including sumoylation and phosphorylation. Clinically, DAXX function is linked to alpha-thalassemia/mental retardation syndrome through its association with ATRX, and it is also implicated in the pathogenesis of myeloid leukemia. |
检测原理