Overview
| 别名 | Transcription factor 20; TCF-20; Nuclear factor SPBP; Protein AR1; Stromelysin-1 PDGF-responsive element-binding protein; SPRE-binding protein |
| 基因名 | TCF20 |
| UniProt ID | Q9UGU0 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 5C5-U4-F5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 211 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Transcription factor 20 (TCF20) is a nuclear protein encoded by the TCF20 gene that functions primarily as a transcriptional coactivator, binding to regulatory DNA elements such as the platelet-derived growth factor-responsive element in the matrix metalloproteinase 3 (MMP3) promoter and controlling stromelysin expression. TCF20 displays DNA-binding and transactivation activities, enhancing the function of multiple transcription factors including JUN, SP1, PAX6, and others, thereby influencing a wide range of physiological processes such as DNA damage repair, epigenetic gene regulation, protein modification, signal transduction, cellular proliferation, differentiation, apoptosis, neuronal and synaptic development, immune response, and lipid metabolism. The protein contains several functional domains, including nuclear localization sequences, AT-hook, DNA-binding, PHD, and zinc-finger domains, and alternative splicing results in different isoforms. Pathogenic variants in TCF20, particularly those causing loss of key domains, are associated with neurodevelopmental disorders, as they disrupt its regulatory functions and affect the activity of related transcription factors, leading to developmental and neurological abnormalities. |
检测原理