Overview
| 别名 | STEAP1 protein; Six-transmembrane epithelial antigen of prostate 1 |
| 基因名 | STEAP1 |
| UniProt ID | Q9UHE8 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 1B6-X2-R8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 39 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | STEAP family member 1 (STEAP1) is a six-transmembrane domain protein composed of 339 amino acids, encoded by a gene located on chromosome 7q21.13. Structurally, STEAP1 features two intracellular and three extracellular loops, with both termini facing the cytoplasm, and contains a C-terminal domain homologous to b-type cytochrome metalloreductases, suggesting a role in electron transport. Recent studies indicate that STEAP1 can participate in iron metabolism by transferring electrons through its B-heme group and potentially forming heterotrimers with STEAP4, which possesses NADPH-binding capability. Cryo-EM analysis reveals a trimeric structure with conserved FAD- and heme-binding sites, supporting its function as a transmembrane oxidoreductase involved in iron reduction. STEAP1 is predominantly expressed in prostate tissue and is highly upregulated in various cancers, particularly prostate cancer, where it enhances cell proliferation and metastatic potential. |
检测原理