Overview
| 别名 | Adhesion G protein-coupled receptor E2; EGF-like module receptor 2; EGF-like module-containing mucin-like hormone receptor-like 2; CD antigen CD312 |
| 基因名 | ADGRE2 |
| UniProt ID | Q9UHX3 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 2I5-L7-N7 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 90 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Adhesion G protein-coupled receptor E2 (ADGRE2) is a cell surface receptor found in various immune system cells, particularly mast cells. It consists of two subunits: an alpha subunit on the cell's outer surface and a beta subunit spanning the cell membrane. ADGRE2 plays a role in cell adhesion by binding to chondroitin sulfate on glycosaminoglycan chains. The protein promotes granulocyte chemotaxis, degranulation, and adhesion, and in macrophages, it stimulates the release of inflammatory cytokines. ADGRE2 undergoes GPS autoproteolysis before reaching the plasma membrane, and its distribution within lipid rafts may affect cell signaling. A mutation in the ADGRE2 gene (Cys492Tyr) has been associated with vibratory urticaria, a condition where vibration or friction on the skin causes allergy symptoms. This mutation leads to a less stable interaction between the protein's subunits, potentially triggering mast cell reactions upon mechanical stimulation. |
检测原理