Overview
| 别名 | G patch domain-containing protein 8 |
| 基因名 | GPATCH8 |
| UniProt ID | Q9UKJ3 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5P1-Z1-C5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 164 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | G-patch domain-containing protein 8 (GPATCH8) is a human protein encoded by the GPATCH8 gene that features an RNA-processing domain, a zinc finger domain, a lysine-rich region, and a serine-rich region. GPATCH8 is functionally involved in RNA splicing, particularly in quality control of branchpoint selection during the splicing process. It interacts with the RNA helicase DHX15 and opposes another G-patch protein, SUGP1, affecting RNA splicing dynamics. Mutations in GPATCH8 have been linked to diseases including hyperuricemia associated with osteogenesis imperfecta, and importantly, the protein modulates aberrant RNA splicing driven by SF3B1 mutations, which are prevalent in hematologic malignancies such as myelodysplastic syndromes and leukemias. Silencing GPATCH8 has been shown to correct a significant portion of mutant SF3B1-induced mis-splicing and improve hematopoiesis in models, highlighting it as a potential therapeutic target in SF3B1-mutant cancers and other splicing-related blood disorders. |
检测原理