Overview
| 别名 | Cilia- and flagella-associated protein 45; Coiled-coil domain-containing protein 19; Nasopharyngeal epithelium-specific protein 1 |
| 基因名 | CFAP45 |
| UniProt ID | Q9UL16 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9C5-A6-X8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 65 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Cilia and flagella associated protein 45 (CFAP45) is a cytoskeletal protein integral to the axonemal structure of motile cilia and flagella, where it interacts with dynein ATPases and adenylate kinase to regulate adenine nucleotide homeostasis, particularly by binding AMP and facilitating microtubule sliding necessary for effective ciliary and flagellar beating. CFAP45 contains domains that enable stable three-dimensional folding and specific interactions with other proteins, contributing to its role in the axonemal module that controls motility. Deficiency of CFAP45 in humans and mice leads to a motile ciliopathy characterized by normal ciliary morphology but impaired function, manifesting clinically as situs inversus totalis and asthenospermia due to dyskinetic beating of nodal cilia and sperm flagella. Restoration of nucleotide balance with AMP or ADP can rescue the motility defect, highlighting CFAP45’s essential role in maintaining proper ciliary and flagellar movement. |
检测原理