Overview
| 别名 | Zinc finger protein 346; Just another zinc finger protein |
| 基因名 | ZNF346 |
| UniProt ID | Q9UL40 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2Z3-H9-E3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 32 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Zinc finger protein 346 (ZNF346) is a nucleolar protein characterized by C2H2-type zinc finger domains that enable high-affinity binding to double-stranded RNA (dsRNA) and RNA/DNA hybrids. These domains are essential for its nucleolar localization and its ability to interact with nucleic acids without sequence specificity. ZNF346 plays a significant role in supporting cell growth and survival, particularly by providing neuronal protection through the inhibition of cell cycle re-entry via the stimulation of the p21 gene. It is expressed across various human tissues, with prominent levels found in the brain. Through its nucleic acid and enzyme binding activities, ZNF346 contributes to the regulation of cellular proliferation and the maintenance of genomic stability. Its involvement in these fundamental processes underscores its importance in developmental biology and neuroprotection. |
检测原理