Overview
| 别名 | Myelin transcription factor 1-like protein; MyT1-L; MyT1L |
| 基因名 | MYT1L |
| UniProt ID | Q9UL68 |
| 反应种属 | Human,Rat |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8D6-W2-Q2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 133 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Myelin transcription factor 1-like protein (MYT1L) is a crucial transcription factor that plays a significant role in neuronal development and differentiation. It is characterized by the presence of C2HC-type zinc fingers and a MYT1 domain, which are thought to function as transcriptional repressors. MYT1L is primarily expressed in the developing brain and is essential for enhancing neuronal identity by actively repressing several developmental pathways, including WNT and NOTCH. Dysregulation of MYT1L has been associated with various neurodevelopmental disorders, particularly autism spectrum disorder (ASD) and intellectual disability. Mutations or deletions in the MYT1L gene can lead to neurodevelopmental delays, behavioral phenotypes, and altered gene expression patterns that resemble those observed in ASD patients. |
检测原理