Overview
| 别名 | Coronin-1C; Coronin-3; hCRNN4 |
| 基因名 | CORO1C |
| UniProt ID | Q9ULV4 |
| 反应种属 | Human |
| 应用 | WB,IP,CHIP |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9J2-H2-H5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 53 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Coronin 1C (CORO1C) is an actin-binding protein belonging to the WD repeat protein family, characterized by multiple WD repeat domains that facilitate the formation of multiprotein complexes and are involved in essential cellular processes such as cytoskeletal organization, cell cycle progression, signal transduction, and apoptosis. CORO1C plays a specialized role in regulating branched actin structures, particularly at endosomal membranes, where it confines actin to specific regions to control endosome fission and receptor sorting, thereby influencing cell shape, adhesion, and intracellular trafficking. In terms of disease association, CORO1C is frequently upregulated in several cancers, including colorectal, hepatocellular, and gastric cancers, where its overexpression correlates with increased tumor invasiveness, metastasis, and poor patient prognosis, highlighting its potential as a biomarker for aggressive cancer phenotypes. |
检测原理