Overview
| 别名 | Syntaxin-8 |
| 基因名 | STX8 |
| UniProt ID | Q9UNK0 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 1I3-J1-O3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 26 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:100-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Syntaxin 8 (STX8) is a member of the syntaxin family of proteins involved in intracellular vesicle trafficking, particularly mediating protein transport between early and late endosomes as well as retrograde transport from the Golgi to the endoplasmic reticulum. It contains three N-terminal helices, a SNARE domain, and a C-terminal transmembrane domain, and forms SNARE complexes with proteins such as syntaxin 7, vti1b, and endobrevin, playing a key role in homotypic fusion of late endosomes. STX8 also modulates the trafficking of specific proteins like the TrkA receptor and the potassium channel TASK-1 by influencing their surface expression through endosomal and post-biosynthetic pathways. In terms of disease relevance, alterations in STX8-mediated trafficking impact cellular functions such as receptor surface levels that can affect signaling; for example, defects in STX8 influence cellular transport processes critical in kidney function and immune cell cytotoxicity, linking STX8 dysfunction to pathologies involving vesicle trafficking and cellular transport disorders. |
检测原理