Overview
| 别名 | FAS-associated factor 1; hFAF1; UBX domain-containing protein 12; UBX domain-containing protein 3A |
| 基因名 | FAF1 |
| UniProt ID | Q9UNN5 |
| 反应种属 | Human |
| 应用 | IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 8J5-S1-I2 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 73 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:500-1:1000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Fas-associated factor 1 (FAF1) is a 74-kDa multifunctional scaffolding protein involved in apoptosis and cellular regulation. It binds directly to the Fas receptor and components of the Fas-death-inducing signaling complex (Fas-DISC) such as FADD and caspase-8, facilitating Fas-mediated apoptosis by acting upstream of caspase-8. FAF1 contains multiple ubiquitin-related domains (UBA, UBL1, UBL2, UBX) which enable interactions with ubiquitinated proteins and the valosin-containing protein complex, implicating it in ubiquitin-mediated proteasomal degradation and endoplasmic reticulum-associated protein degradation (ERAD). FAF1 also negatively regulates the NF-κB signaling pathway by inhibiting IKK activation and preventing nuclear translocation of NF-κB. Dysregulation of FAF1 is linked to diseases including cancer, where decreased FAF1 expression may contribute to tumor progression, and neurodegenerative disorders through its role in cell survival and death. FAF1 additionally influences antiviral immune responses by regulating type I interferon production during RNA virus infections, highlighting its diverse roles in cell death and immune signaling. |
检测原理