Overview
| 别名 | Leydig cell tumor 10 kDa protein homolog |
| 基因名 | C19orf53 |
| UniProt ID | Q9UNZ5 |
| 反应种属 | Human |
| 应用 | WB,IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2U7-N6-T5 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 10 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000; IHC-1:3000-1:4000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Chromosome 19 open reading frame 53 (C19orf53) known as Leydig cell tumor 10 kDa protein homolog. It belongs to the UPF0390 family and may have a potential role in hypercalcemia of malignancy. C19orf53 exhibits chaperone-like properties and has been identified as a "heat-resistant obscure" or "Hero" protein, displaying resilience and the ability to suppress pathological protein aggregation. It plays a role in mediating excessive cell proliferation, leading to metabolic imbalance and increased oxidative stress in response to toxins. Recent studies have associated C19orf53 with ischemic stroke risk, with genetic variations in the gene potentially influencing disease susceptibility. Additionally, C19orf53 has been implicated in various biological pathways, including rRNA biogenesis, ovarian cancer, and Zika virus replication. |
检测原理