Overview
| 别名 | Proteasome maturation protein; Proteassemblin; Protein UMP1 homolog; hUMP1; Voltage-gated K channel beta subunit 4.1 |
| 基因名 | POMP |
| UniProt ID | Q9Y244 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7F6-C8-Q9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 15 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Proteasome maturation protein (POMP) is an essential chaperone that orchestrates the biogenesis of the 20S proteasome core complex, a central component of the cellular protein degradation machinery. POMP localizes to the endoplasmic reticulum (ER), where it binds to α1–7 rings of the assembling proteasome, recruits β-subunits in a stepwise manner, and mediates the association of precursor complexes with the ER membrane, thereby coordinating the assembly and maturation process to ensure efficient formation of functional proteasomes. The degradation of POMP itself is tightly regulated by a dual-checking mechanism, with the α5 subunit sensing POMP degradation to trigger the release of other assembly chaperones, thus safeguarding the fidelity of proteasome maturation. Defects in POMP function or expression can impair proteasome assembly, leading to reduced proteolytic capacity and contributing to diseases characterized by protein aggregation and impaired protein homeostasis, such as certain autoinflammatory syndromes and age-related disorders. |
检测原理