Overview
| 别名 | Tumor necrosis factor ligand superfamily member 13B; B lymphocyte stimulator; BLyS; B-cell-activating factor; BAFF; Dendritic cell-derived TNF-like molecule; TNF- and APOL-related leukocyte expressed ligand 1; TALL-1; CD antigen CD257) [Cleaved into: Tumor necrosis factor ligand superfamily member 13b; membrane form; Tumor necrosis factor ligand superfamily member 13b; soluble form] |
| 基因名 | TNFSF13B |
| UniProt ID | Q9Y275 |
| 反应种属 | Human,Mouse |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 2H4-G5-Y3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 31 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | TNF superfamily member 13b (TNFSF13B), also known as B-cell activating factor (BAFF), is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. It is encoded by the TNFSF13B gene located on chromosome 13q33.3. This protein acts as a potent B cell activator, playing a crucial role in the proliferation and differentiation of B cells. It is expressed in B cell lineage cells and interacts with receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. BAFF is involved in the stimulation of B- and T-cell function and the regulation of humoral immunity. Abnormal expression of BAFF has been associated with autoimmune diseases and certain types of cancers, such as chronic lymphocytic leukemia, B-cell lymphoma, and multiple myeloma. The protein exists in both membrane-bound and soluble forms, with the soluble form being generated through cleavage from the membrane-bound form. |
检测原理