Overview
| 别名 | Sialic acid-binding Ig-like lectin 7; Siglec-7; Adhesion inhibitory receptor molecule 1; AIRM-1; CDw328; D-siglec; QA79 membrane protein; p75; CD antigen CD328 |
| 基因名 | SIGLEC7 |
| UniProt ID | Q9Y286 |
| 反应种属 | Human,Mouse |
| 应用 | WB,IP,CHIP,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2b |
| 克隆号 | 4K7-I6-V8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 51 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; IP-1:100; CHIP-1:100; ELISA-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Sialic acid-binding Ig-like lectin 7 (SIGLEC7) is a member of the Siglec family of proteins, primarily expressed on natural killer (NK) cells and some myeloid cells, where it plays a crucial role in immune regulation. SIGLEC7 recognizes sialylated glycoconjugates, facilitating cell-cell interactions and modulating immune responses. Its binding to sialic acid-containing ligands can inhibit immune activation, promoting immune tolerance and potentially contributing to tumor evasion. Dysregulation of SIGLEC7 has been implicated in various diseases, particularly in cancer, where its expression on tumor-infiltrating lymphocytes can lead to immune suppression, allowing tumors to grow unchecked. Additionally, elevated SIGLEC7 levels have been associated with chronic inflammatory conditions such as rheumatoid arthritis and multiple sclerosis. |
检测原理