Overview
| 别名 | Signaling threshold-regulating transmembrane adapter 1; SHP2-interacting transmembrane adapter protein; Suppression-inducing transmembrane adapter 1; gp30/40 |
| 基因名 | SIT1 |
| UniProt ID | Q9Y3P8 |
| 反应种属 | Human,Mouse |
| 应用 | IHC-P,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 7H6-Q9-R1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 21 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Signaling threshold-regulating transmembrane adapter 1 (SIT1) is a member of the solute carrier family and functions primarily as a proline transporter. This protein is characterized by its ability to facilitate the uptake of proline, an amino acid that plays essential roles in various physiological processes, including neurotransmission and cellular metabolism. SIT1 is particularly important in the central nervous system, where it regulates proline concentrations that modulate the activity of neurotransmitter receptors, such as glycine and NMDA receptors. Dysregulation of SIT1 has been linked to several diseases, including iminoglycinuria, a genetic disorder characterized by abnormal amino acid transport leading to elevated levels of proline and glycine in urine. Furthermore, polymorphisms in the SIT1 gene have been associated with neurological conditions and retinal diseases, influencing retinal pigment epithelium function and potentially contributing to degenerative macular diseases. |
检测原理