Overview
| 别名 | T-box transcription factor TBX22; T-box protein 22 |
| 基因名 | TBX22 |
| UniProt ID | Q9Y458 |
| 反应种属 | Human,Mouse |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8H9-M4-J8 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 57 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | T-box transcription factor 22 (TBX22) is a member of the phylogenetically conserved T-box family of transcription factors, characterized by a conserved N-terminal DNA-binding domain. It functions as a critical transcriptional regulator during embryonic development, with a primary role in palatogenesis and the morphogenesis of the tongue. TBX22 is expressed in the palatal shelves and is essential for the proper formation of the secondary palate. Clinically, mutations in the TBX22 gene are the primary cause of X-linked cleft palate with ankyloglossia (CPX). This disorder is characterized by phenotypes ranging from complete secondary palate clefts to bifid uvula, often accompanied by ankyloglossia (tongue-tie). The loss of TBX22 function disrupts normal craniofacial development, establishing it as a major determinant in the etiology of these congenital anomalies. |
检测原理