Overview
| 别名 | Lysine-specific demethylase 3A; JmjC domain-containing histone demethylation protein 2A; Jumonji domain-containing protein 1A; [histone H3]-dimethyl-L-lysine(9) demethylase 3A |
| 基因名 | KDM3A |
| UniProt ID | Q9Y4C1 |
| 反应种属 | Human,Mouse |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 8P5-C5-Z9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 147 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:200 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Lysine demethylase 3A (KDM3A), also known as JMJD1A, is a histone demethylase that specifically targets mono- and dimethylated lysine 9 on histone H3, playing a crucial role in gene expression regulation and transcriptional activation, particularly in hormone-dependent pathways. KDM3A is implicated in various biological processes, including spermatogenesis and metabolic regulation, contributing to obesity resistance by modulating genes such as PPARα and UCP1. Dysregulation of KDM3A has been associated with several diseases, notably cancer; it facilitates chemoresistance and cancer stemness by demethylating key proteins like p53, thereby inhibiting apoptotic pathways. Additionally, KDM3A's overexpression is linked to prostate cancer progression through its interaction with androgen receptors and hypoxia-inducible factors, making it a potential therapeutic target for cancer treatment. |
检测原理