Overview
| 别名 | Receptor-interacting serine/threonine-protein kinase 3; RIP-like protein kinase 3; Receptor-interacting protein 3; RIP-3 |
| 基因名 | RIPK3 |
| UniProt ID | Q9Y572 |
| 反应种属 | Human |
| 应用 | WB,ELISA |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 6B4-D2-Q4 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 56 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000; ELISA-1:250-1:500 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Receptor-interacting serine/threonine-protein kinase 3 (RIPK3) is a critical regulator of programmed necrosis, specifically necroptosis, which is an inflammatory form of cell death. It is part of the receptor-interacting protein (RIP) kinase family and plays a pivotal role in cellular responses to stress and inflammation. RIPK3 functions by forming a complex known as the necrosome with RIPK1 and mixed lineage kinase domain-like protein (MLKL), which is essential for executing necroptosis. Dysregulation of RIPK3 has been implicated in various diseases, particularly inflammatory conditions and cancer. For instance, excessive RIPK3 activity can contribute to tissue damage in conditions such as ischemia-reperfusion injury and chronic inflammatory diseases, while reduced RIPK3 function may lead to impaired necroptosis, allowing for tumor survival and progression. |
检测原理