Overview
| 别名 | Ectonucleoside triphosphate diphosphohydrolase 2; NTPDase 2; CD39 antigen-like 1; Ecto-ATP diphosphohydrolase 2; Ecto-ATPDase 2; Ecto-ATPase 2 |
| 基因名 | ENTPD2 |
| UniProt ID | Q9Y5L3 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 8X4-A1-N6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 53 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Ectonucleoside triphosphate diphosphohydrolase 2 (ENTPD2), also known as NTPDase2, is an integral membrane protein and a member of the E-NTPDase family, primarily responsible for hydrolyzing extracellular nucleoside triphosphates and diphosphates, such as ATP and ADP, to regulate purinergic signaling in various tissues. ENTPD2 is widely expressed in multiple organs, including the brain, liver, kidney, and immune tissues, and plays a key role in modulating neurotransmission, inflammation, and vascular function. The protein is subject to alternative splicing, resulting in multiple transcript variants, and its expression can be influenced by extracellular ATP and anti-inflammatory cytokines like IL-10, particularly in astrocytes during neuroinflammatory conditions. Clinically, ENTPD2 has been identified as a prognostic marker in several cancers, including kidney renal clear cell carcinoma, liver hepatocellular carcinoma, and lung adenocarcinoma, and is associated with diseases such as severe COVID-19 and frontal sinus disorders. |
检测原理