Overview
| 别名 | Sorting nexin-11 |
| 基因名 | SNX11 |
| UniProt ID | Q9Y5W9 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 2R2-P5-L9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 30 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Sorting nexin 11 (SNX11) is a phosphoinositide-binding protein characterized by a unique extended PX (PXe) domain, which includes additional α-helices essential for its function in intracellular endosomal trafficking and protein sorting. This PX domain specifically binds to phosphatidylinositols found in organelle membranes, facilitating SNX11's recruitment to vesicles and its involvement in membrane trafficking pathways. Structurally, the PXe domain differentiates SNX11 from other sorting nexins by its novel two α-helices at the C-terminus, crucial for modulating vacuolation activity and protein interactions. Functionally, SNX11 assists in trafficking proteins such as the TRPV3 ion channel to lysosomes for degradation, thus playing roles in lysosomal degradation pathways and maintaining protein homeostasis within cells. Its regulatory role in membrane trafficking suggests potential links to neurological and cellular trafficking disorders through disrupted protein sorting and degradation mechanisms. |
检测原理