徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
BACH1 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2610974 |
| 100ul | WGD-Z-2610974 |
详细参数
| 别名 | Transcription regulator protein BACH1; BTB and CNC homolog 1; HA2303);BTB domain and CNC homolog 1 |
| 基因名 | BACH1 |
| UniProt ID | O14867 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 9R8-D2-H3 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 81 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:4000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Transcription regulator protein BACH1 (BACH1) is a member of the Cap 'n' Collar and basic region leucine zipper (CNC-bZIP) family of transcription factors. It contains a Broad-complex, Tramtrack, and Bric-à-brac (BTB) domain, six cysteine-proline (CP) motifs, and a basic leucine zipper (bZIP) domain, which enable it to bind DNA and form heterodimers with small Maf proteins[1][2]. BACH1 primarily functions as a transcriptional repressor, regulating the expression of genes involved in oxidative stress response, heme homeostasis, cell cycle, and immunity. Dysregulation of BACH1 has been implicated in various diseases, including cancer, where it can promote tumor progression and metastasis by altering the expression of genes related to angiogenesis, epithelial-mesenchymal transition, and stemness. Additionally, BACH1 has been linked to neurodegenerative disorders and autoimmune diseases. |