徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
CCL16 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2610995 |
| 100ul | WGD-Z-2610995 |
详细参数
| 别名 | C-C motif chemokine 16; Chemokine CC-4; HCC-4; Chemokine LEC; IL-10-inducible chemokine; LCC-1; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant; LMC; Monotactin-1; MTN-1; NCC-4; Small-inducible cytokine A16 |
| 基因名 | CCL16 |
| UniProt ID | O15467 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 5E4-A7-A1 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 13 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:1000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | C-C motif chemokine ligand 16 (CCL16) is a member of the CC chemokine family, characterized by two adjacent cysteines and a canonical chemokine domain. CCL16 is a highly basic, secreted protein primarily synthesized by hepatocytes and circulates in the blood as a full-length protein, with little response to inflammatory mediators. It exhibits chemotactic activity for lymphocytes and monocytes but not neutrophils, and also displays potent myelosuppressive effects by suppressing proliferation of myeloid progenitor cells. The C-terminal extension may modulate its biological activity by limiting glycosaminoglycan binding site accessibility. Disease associations include inhibition of liver cirrhosis progression via inactivation of hepatic stellate cells and maintenance of stem cell-like properties in certain contexts. |