徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
EIF4G3 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611004 |
| 100ul | WGD-Z-2611004 |
详细参数
| 别名 | Eukaryotic translation initiation factor 4 gamma 3; eIF-4-gamma 3; eIF-4G 3; eIF4G 3; eIF-4-gamma II; eIF4GII |
| 基因名 | EIF4G3 |
| UniProt ID | O43432 |
| 反应种属 | Human |
| 应用 | IHC-P |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG1 |
| 克隆号 | 8J1-U6-E6 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 176 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | IHC-1:200-1:250 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Eukaryotic translation initiation factor 4 gamma 3 (EIF4G3) is a key component of the eIF4F protein complex, which plays a central role in the initiation of eukaryotic translation by recognizing the mRNA cap structure and facilitating the recruitment of ribosomes to mRNA, as well as unwinding secondary structures at the 5' end of mRNAs to promote efficient translation initiation. EIF4G3 acts as a scaffold protein, organizing other initiation factors and mRNA, and is notably enriched in the nucleus of spermatocytes, particularly within the XY body, suggesting a specialized role in regulating mRNA metabolism and translation during meiosis and spermatogenesis. Mutations in EIF4G3 have been shown in mouse models to cause male infertility due to meiotic arrest, likely by impairing the translation of key proteins such as HSPA2, which is essential for progression through meiosis. Additionally, aberrant expression of circ-EIF4G3 has been implicated in promoting proliferation, invasion, and migration in gastric cancer, highlighting its relevance in disease contexts. |