徐州威格顿生物科技有限公司
威格顿生物
Weigedun Biotechnology
BCL2L11 Mouse mAb
规格信息
| 规格 | 货号 |
|---|---|
| 50ul | WGD-Z-2611005 |
| 100ul | WGD-Z-2611005 |
详细参数
| 别名 | Bcl-2-like protein 11; Bcl2-L-11; Bcl2-interacting mediator of cell death |
| 基因名 | BCL2L11 |
| UniProt ID | O43521-2 |
| 反应种属 | Human |
| 应用 | WB |
| 宿主 | Mouse |
| 偶联物 | Unconjugated |
| 修饰 | Unmodified |
| 亚型 | IgG2a |
| 克隆号 | 8L7-A4-U9 |
| 克隆性 | Monoclonal Antibody |
| 分子量 | Calculated MW: 15 kDa |
| 纯化方式 | Affinity Purified |
| 产品形式 | Liquid |
| 推荐稀释比 | WB-1:2000 |
| 存储缓冲液 | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.09% sodium azide |
| 保存温度 | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| 背景信息 | Bcl-2-like protein 11 (BCL2L11), also known as BIM, is a pro-apoptotic member of the BCL-2 protein family. It contains a BH3 domain and interacts with other BCL-2 family proteins to promote apoptosis. BCL2L11 exists in multiple isoforms, with BimL and BimS being more potent inducers of cell death than BimEL. The protein is regulated at transcriptional, translational, and post-translational levels, playing crucial roles in immune responses and tissue homeostasis. BCL2L11 is involved in various cellular processes, including anoikis and autophagy regulation. Dysregulation of BCL2L11 has been implicated in several diseases, including cancer and autoimmune disorders. In cancer, suppression of BCL2L11 expression can contribute to tumor progression and metastasis. Additionally, genetic variants in BCL2L11 have been associated with an increased risk of developing ulcerative forms of Buruli ulcer, a mycobacterial skin infection. |